Resveratrol and its use in dermatology
Resveratrol and its use in dermatology RESVERATROL is a natural polyphenolic antioxidant that is present in high amounts in more than 70 plant species, including grapes and berries.
In nature, Resveratrol serves to protect plants from ultraviolet light, infections or other environmental factors. This is why science looked at this compound, which has proved to be a molecule that would help extend the average life of cells.
Some of the beneficial effects of Resveratrol include neuroprotection, cardioprotection and activity to combat diabetes and some tumors. It has also been proven its broad spectrum of anti-inflammatory benefits as inhibiting a variety of inflammatory markers such as cox2, IL2, IL 6, IL8 and vascular endothelial growth factor.
In topical application, the use of Resveratrol has been a real challenge, since contact with ultraviolet light is easily isomerized to the “cis” form, which is the least desirable for its antioxidant action.
Another important challenge has been that due to its hydrophobic nature, it is very difficult to find it in concentrations that are really effective.
Aging skin and Resveratrol
Oxidative Stress is known to contribute to the aging of the skin. Free radicals are naturally produced by us as well as by extrinsic factors, such as ultraviolet light, pollution, food and cigarette smoke. Reactive Oxygen Species (ROS) accumulate in cells where they damage lipid membranes and DNA.
Resveratrol has unique characteristics within antioxidants in many ways, as it serves as a neutralizer of free radicals by reducing the action of reactive oxygen species, such as Hydroxyl, Superoxide and Metal radicals.
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